Human Dectin-1 Deficiency and Mucocutaneous Fungal Infections
نویسندگان
چکیده
منابع مشابه
Dectin-1 deficiency and mucocutaneous fungal infections.
n engl j med 362;4 nejm.org january 28, 2010 367 (HAPO) study.3,4 Fifteen institutional review boards approved our protocol, and none rejected the trial on ethical grounds. In addition, an independent data and safety monitoring committee regularly reviewed the trial. Some participants would not even have met the criteria for gestational diabetes (more evidence of clinical equipoise). We strongl...
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Mucocutaneous fungal infections are typically found in patients who have no known immune defects. We describe a family in which four women who were affected by either recurrent vulvovaginal candidiasis or onychomycosis had the early-stop-codon mutation Tyr238X in the beta-glucan receptor dectin-1. The mutated form of dectin-1 was poorly expressed, did not mediate beta-glucan binding, and led to...
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ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 2009
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejmoa0901053